Oropharyngeal cancer: a potential consequence of concomitant HPV and HIV infection
- 1 September 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Oncology
- Vol. 21 (5), 439-444
- https://doi.org/10.1097/cco.0b013e32832f3e1b
Abstract
Oral human papillomavirus (HPV) infection is the principal cause of a distinct form of oropharyngeal cancer (OPCA) that has been rising in incidence in the United States since 1973, particularly among young men. The possible contribution of the HIV-epidemic to this increase is unclear. Incidence rates for HPV-related OPCA increased with age and were strongly influenced by year of birth in the United States (cohort effect). Persons with HIV/AIDS are at increased risk ( approximately two to six-fold) for OPCA relative to the general population. However, this excess risk may be attributable to tobacco smoking rather than the three-fold higher prevalence of oral HPV infection in this population. Consistent with a viral attribution, however, is the apparent increase in risk of OPCA with severity of AIDS-related immunosuppression. Analogous to other HPV-related cancers (e.g. cervical and anal cancer), trends over time do not appear to be influenced by highly active antiretroviral (HAART) therapy. Healthcare providers may encounter HPV-related OPCA more frequently among individuals with HIV/AIDS as this population ages and due to the strong birth cohort effects observed in the general population. However, there is no evidence in support of different incidence trends over time among persons with and without HIV/AIDS.Keywords
This publication has 58 references indexed in Scilit:
- Human Papillomavirus in HNSCC: Recognition of a Distinct Disease TypeHematology/Oncology Clinics of North America, 2008
- Cystic lymph node metastasis in patients with head and neck cancer: An HPV‐associated phenomenonHead & Neck, 2008
- Distinct Risk Factor Profiles for Human Papillomavirus Type 16–Positive and Human Papillomavirus Type 16–Negative Head and Neck CancersJNCI Journal of the National Cancer Institute, 2008
- High Association of Human Papillomavirus Infection with Oral Cancer: A Case-Control StudyArchives of Medical Research, 2007
- Case–Control Study of Human Papillomavirus and Oropharyngeal CancerNew England Journal of Medicine, 2007
- Global Cancer Statistics, 2002CA: A Cancer Journal for Clinicians, 2005
- Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic ReviewCancer Epidemiology, Biomarkers & Prevention, 2005
- Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck CancersJNCI Journal of the National Cancer Institute, 2000
- Human papillomavirus is a necessary cause of invasive cervical cancer worldwideThe Journal of Pathology, 1999
- Oral Cancer Risk in Relation to Sexual History and Evidence of Human Papillomavirus InfectionJNCI Journal of the National Cancer Institute, 1998