Skeletal lipidomics: regulation of bone metabolism by fatty acid amide family
- 12 July 2011
- journal article
- review article
- Published by Wiley in British Journal of Pharmacology
- Vol. 163 (7), 1441-1446
- https://doi.org/10.1111/j.1476-5381.2011.01474.x
Abstract
There is increasing evidence demonstrating that fatty acid derivatives play a key regulatory role in a variety of tissues. However, the study of skeletal lipidomics is just emerging and global strategies, such as targeted lipidomics, have not been applied to bone tissue. Such strategies hold great promises as in the case of genomics and proteomics. A partial profile of endocannabinoids and endocannabinoid-like compounds has demonstrated the presence of several long-chain fatty acid amides (FAAs), some of which displaying potent effects on osteoblasts, the bone forming cells and osteoclasts, the bone resorbing cells. In the skeleton, the FAAs activate the CB(1) cannabinoid receptor present in sympathetic nerve terminals as well as CB(2) cannabinoid receptor, the Gi-protein coupled receptor GPR55, and the transient receptor potential vanilloid type ion channel expressed by osteoblasts and/or osteoclasts. This review on the skeletal FAA system focuses on the production of FAAs in the skeleton and their net bone anabolic and anti-catabolic activity resulting from the stimulation of bone formation and inhibition of bone resorption. As the FAA family holds great promise as a basis for the treatment of osteoporosis and other diseases involving bone, further studies should aim towards the complete profiling of these lipids and their receptors in bone tissue, followed by elucidation of their function and mechanism of action.Keywords
This publication has 54 references indexed in Scilit:
- Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilizationBlood, 2011
- Enzymological studies on the biosynthesis of N-acylethanolaminesBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
- International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1and CB2Published by American Society for Pharmacology & Experimental Therapeutics (ASPET) ,2010
- Oleoyl serine, an endogenous N -acyl amide, modulates bone remodeling and massProceedings of the National Academy of Sciences, 2010
- CB2 cannabinoid receptor targets mitogenic Gi protein–cyclin D1 axis in osteoblastsJournal of Bone and Mineral Research, 2010
- N‐Acyl amino acids and N‐acyl neurotransmitter conjugates: neuromodulators and probes for new drug targetsBritish Journal of Pharmacology, 2010
- Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer‐induced painBritish Journal of Pharmacology, 2010
- The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivoProceedings of the National Academy of Sciences of the United States of America, 2009
- The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signalingThe FASEB Journal, 2007
- Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone RemodelingMolecular Pharmacology, 2006