Hypertension pharmacogenomics: in search of personalized treatment approaches

Abstract

Hypertension is an important, modifiable risk factor for cardiovascular and kidney disease Rates of blood pressure control are substantially below the desired levels globally, with many factors contributing to poor blood pressure control Pharmacogenomics and other 'omics' approaches could help to identify useful biomarkers for a more personalized or precision approach to antihypertensive treatment strategies Validating and replicating antihypertensive pharmacogenomics signals will require large sample sizes and will probably not yield a single signal with a large effect size, but rather multiple signals with small effect sizes As technology continues to evolve and genetic and other 'omics' data become available from collaborative studies, identification of biomarkers of blood pressure response might be possible