FACILE SYNTHESIS OF SATURATED EIGHT-MEMBERED RING LACTONES
- 1 January 2001
- journal article
- Published by Taylor & Francis Ltd in Synthetic Communications
- Vol. 31 (11), 1781-1791
- https://doi.org/10.1081/scc-100104408
Abstract
The synthesis of functionalized saturated eight-membered ring lactones from their corresponding seco acids is a very facile process using conventional macrolactonization protocols. This heretofore unrecognized and overlooked strategy is illustrated for several examples. A possible explanation for the success of this approach is also presented.Keywords
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