Hypercholesterolemia Reduces Collateral Artery Growth More Dominantly Than Hyperglycemia or Insulin Resistance in Mice
Open Access
- 1 June 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 26 (6), 1383-1390
- https://doi.org/10.1161/01.atv.0000219234.78165.85
Abstract
Objective— Collateral artery development (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease, may be deregulated by vascular risk factors, eg, diabetes or hypercholesterolemia. Here, we compared the effects of either disturbed glucose metabolism or disturbed lipid metabolism on arteriogenesis. Methods and Results— Femoral artery occlusion was performed in streptozotocin(STZ)-treated mice, nonobese diabetic (NOD) mice, and insulin-resistant Ob/Ob mice on regular diet, and APOE3*Leiden mice on different hypercholesterolemic diets. Angiography and laser Doppler perfusion analysis of hindlimbs were performed postoperatively. Surprisingly, angiographic arteriogenesis was not impaired in diabetic and insulin-resistant mice. Perfusion recovery in STZ-treated and Ob/Ob mice was only decreased by 19% and 16%, respectively ( P P ≤0.01). Correspondingly, perfusion recovery was 41% decreased in APOE3*Leiden mice ( P P =0.02), but not with triglyceride, free fatty acid, glucose, or insulin levels. Conclusions— Hypercholesterolemia reduces arteriogenesis more dominantly than hyperglycemia or hyperinsulinemia in mice. This suggests that a disturbed lipid metabolism as observed in diabetic patients might be crucial for the impairment of collateral formation.Keywords
This publication has 39 references indexed in Scilit:
- Delayed Arteriogenesis in Hypercholesterolemic MiceCirculation, 2005
- Collateral Artery Growth (Arteriogenesis) After Experimental Arterial Occlusion Is Impaired in Mice Lacking CC-Chemokine Receptor-2Circulation Research, 2004
- Impaired Arteriogenic Response to Acute Hindlimb Ischemia in CD4-Knockout MiceCirculation, 2003
- Rescue of Diabetes-Related Impairment of Angiogenesis by Intramuscular Gene Therapy with Adeno-VEGFThe American Journal of Pathology, 1999
- Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.JCI Insight, 1998
- Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb.JCI Insight, 1998
- Role of lysophosphatidylcholine in the inhibition of endothelial cell motility by oxidized low density lipoprotein.JCI Insight, 1996
- Oxidized low‐density lipoprotein is chemotactic for arterial smooth muscle cells in cultureFEBS Letters, 1990
- Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes MellitusScience, 1976
- Insulin Resistance of the Inherently Obese Mouse—obobNature, 1966