Caloric restriction does not reverse aging-related changes in hippocampal BDNF
- 31 May 2005
- journal article
- research article
- Published by Elsevier BV in Neurobiology of Aging
- Vol. 26 (5), 683-688
- https://doi.org/10.1016/j.neurobiolaging.2004.06.005
Abstract
Caloric restriction (CR) can attenuate the aging-related decline in learning and memory in rats. Understanding the mechanisms underlying this effect could lead to therapies for human memory impairment. We tested the hypotheses that aging is associated with a decline in hippocampal brain-derived neurotrophic factor (BDNF), a growth factor that enhances learning and memory, and that CR increases hippocampal BDNF. We compared BDNF protein levels in hippocampal subregions of young, middle-aged and old rats fed CR or ad libitum (AL) diets. Mean BDNF levels in the dentate gyrus and CA3 did not differ with diet but increased with age. In CA1, BDNF levels were slightly higher in CR than AL rats at middle and old age but did not change across lifespan. These data suggest that mnemonic impairments with age do not reflect a decrease in hippocampal BDNF. Furthermore, if CRs attenuation of aging-related memory changes is mediated by BDNF, then it must be through a small, CA1-specific increase and does not involve reversal of an aging-related decline in BDNF.Keywords
This publication has 57 references indexed in Scilit:
- Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 miceNeurobiology of Aging, 2004
- Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant miceProceedings of the National Academy of Sciences of the United States of America, 2003
- Ventral hippocampal lesions affect anxiety but not spatial learningBehavioural Brain Research, 2002
- Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in miceJournal of Neurochemistry, 2001
- Dietary Restriction Stimulates BDNF Production in the Brain and Thereby Protects Neurons Against Excitotoxic InjuryJournal of Molecular Neuroscience, 2001
- Stress and cognition: are corticosteroids good or bad guys?Trends in Neurosciences, 1999
- Expression of BDNF and trkB as a function of age and cognitive performanceBrain Research, 1998
- Brain-derived neurotrophic factor is reduced in Alzheimer's diseaseMolecular Brain Research, 1997
- Influence of Age and Long-term Dietary Restriction on Plasma Insulin-like Growth Factor-1 (IGF-1), IGF-1 Gene Expression, and IGF-1 Binding ProteinsJournal of Gerontology, 1991
- Effects of long-term restricted feeding on radial maze performance by aged ratsNeurobiology of Aging, 1987