CHOLESTEROL AS RISK FACTOR FOR MORTALITY IN ELDERLY WOMEN
- 22 April 1989
- journal article
- Published by Elsevier BV in The Lancet
- Vol. 333 (8643), 868-870
- https://doi.org/10.1016/s0140-6736(89)92865-1
Abstract
92 women aged 60 years and over (mean 82·2, SD 8·6) living in a nursing home and free from overt cancer were followed-up for 5 years. 53 died during this period; necropsy revealed cancer in only 1 patient. Serum total cholesterol at entry ranged from 4·0 to 8·8 mmol/l (mean 6·3, SD 1·1). Cox's proportional hazards analysis showed a J-shaped relation between serum cholesterol and mortality. Mortality was lowest at serum cholesterol 7·0 mmol/l, 5·2 times higher than the minimum at serum cholesterol 4·0 mmol/l, and only 18 times higher when cholesterol concentration was 88 mmol/l. This relation held true irrespective of age, even when blood pressure, body weight, history of myocardial infarction, creatinine clearance, and plasma proteins were taken into account. The relation between low cholesterol values and increased mortality was independent of the incidence of cancer.This publication has 23 references indexed in Scilit:
- Serum cholesterol and risk of cancer in a cohort of 39,000 men and womenJournal of Clinical Epidemiology, 1988
- SERUM CHOLESTEROL AND MORTALITY RATESThe Lancet, 1987
- Diseases and disorders of aging: An hypothesisJournal of Chronic Diseases, 1986
- SERUM CHOLESTEROL, BLOOD PRESSURE, AND MORTALITY: IMPLICATIONS FROM A COHORT OF 361 662 MENThe Lancet, 1986
- Risk factors for coronary artery disease in persons older than 62 years in a long-term health care facilityThe American Journal of Cardiology, 1986
- Are low cholesterol values associated with excess mortality?BMJ, 1985
- SERUM CHOLESTEROL-THE KNAVE OF HEARTS AND THE JOKERThe Lancet, 1981
- Serum cholesterol and risk of death from cancer and other causes in three Chicago epidemiological studiesJournal of Chronic Diseases, 1981
- The relationship of serum cholesterol to the incidence of cancer in Evans County, GeorgiaJournal of Chronic Diseases, 1980
- PLASMA LIPIDS AND MORTALITY: A SOURCE OF ERRORThe Lancet, 1980