Vitamin A and wound healing
- 31 October 1986
- journal article
- review article
- Published by Elsevier BV in Journal of the American Academy of Dermatology
- Vol. 15 (4), 817-821
- https://doi.org/10.1016/s0190-9622(86)70238-7
Abstract
Retinoids have long been associated with wound healing, but objective data, until recently, have been scarce. Vitamin A deficiency retards repair. Secondly, retinoids restore steroid-retarded repair toward normal. Because vitamin A tends to suppress fibroblasts in cell culture and stimulate steroid-treated macrophages to initiate reparative behavior in tissue, we favor the hypothesis that retinoids are particularly important in macrophagic inflammation, which plays a central role in the control of wound healing. Probably all patients who take anti-inflammatory steroids should control their retinoid intake, but how they should control it is as yet unknown.Keywords
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