Structural maintenance of chromosomes (SMC) proteins
Open Access
- 1 July 1999
- journal article
- review article
- Published by Wiley in European Journal of Biochemistry
- Vol. 263 (1), 6-13
- https://doi.org/10.1046/j.1432-1327.1999.00509.x
Abstract
The evolutionarily‐conserved eukaryotic SMC (structural maintenance of chromosomes) proteins are ubiquitous chromosomal components in prokaryotes and eukaryotes. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. The two most prominent and best‐characterized complexes are cohesin and condensin, necessary for sister chromatid cohesion and chromosome condensation. Here we discuss these functions together with additional roles in gene dosage compensation and DNA recombination.Keywords
This publication has 75 references indexed in Scilit:
- pEg7, a New Xenopus Protein Required for Mitotic Chromosome Condensation in Egg ExtractsThe Journal of cell biology, 1998
- SMC proteins and chromosome structureTrends in Cell Biology, 1998
- Technical Report A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetryInternational Journal of Radiation Biology, 1998
- GFP tagging of budding yeast chromosomes reveals that protein–protein interactions can mediate sister chromatid cohesionCurrent Biology, 1996
- Analysis of the mammalian recombination protein complex RC-1Mutation Research, 1996
- Frontier questions about sister chromatid separation in anaphaseBioEssays, 1995
- Chromosome Structure: Coiling up chromosomesCurrent Biology, 1995
- A Mycoplasma hyorhinis protein with sequence similarities to nucleotide-binding enzymesGene, 1991
- Induction of sister-chromatid exchanges (SCEs) by thymidine and the potentiation of mutagen-induced SCEs in Chinese hamster ovary cellsMutation Research, 1983
- Induction of sister chromatid exchanges by BUdR is largely independent of the BUdR content of DNANature, 1980