Review of the etiopathomechanism of vitiligo: A convergence theory
- 1 August 1993
- journal article
- review article
- Published by Wiley in Experimental Dermatology
- Vol. 2 (4), 145-153
- https://doi.org/10.1111/j.1600-0625.1993.tb00023.x
Abstract
Vitiligo is an acquired melanin pigmentary disorder manifesting itself by expanding depigmented lesions of the skin. To date, the etiopathomechanism of vitiligo has not been convincingly elucidated and a number of seemingly mutually opposed hypotheses with equal likelihood still coexist. Concurrent theories on vitiligo etiology, together with supportive evidence, are reviewed here. Due to the observed variation in clinical manifestations of the disease, it seems likely that the etiology of vitiligo may differ among patients. Therefore several theories on vitiligo etiopathogenesis have been combined to formulate a convergence theory for vitiligo. also presented in this article. This theory stales that stress, accumulation of toxic compounds, infection, autoimmunity. mutations, altered cellular environment and impaired melanocyte migration and or proliferation can all contribute to vitiligo etiopathogenesis in varying proportions.Keywords
This publication has 76 references indexed in Scilit:
- Modulation of Melanocytic Activity by AcetylcholineCells Tissues Organs, 1989
- Regulation of Melanogenesis in MelanocytesPigment Cell Research, 1988
- Audiologic abnormalities in cases of vitiligoJournal of the American Academy of Dermatology, 1987
- Association of HLA-DR4 with vitiligoJournal of the American Academy of Dermatology, 1983
- Autoimmune VitiligoNew England Journal of Medicine, 1977
- Pigment Cells of the Eyes in People with VitiligoNew England Journal of Medicine, 1977
- Ultrastructural investigation of autophagocytosis of melanosomes and programmed death of melanocytes in White Leghorn feathers: a study of morphogenetic events leading to hypomelanosisDevelopmental Biology, 1974
- Epinephrine Induction of White Hair in Aci Rats**From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104.Journal of Investigative Dermatology, 1969
- Catechol O-Methyl Transferase in Skin**From the Section of Dermatology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.Journal of Investigative Dermatology, 1964
- In Vitro Studies on Vitiligo11From the Department of Dermatology (Clarence S. Livingood, M.D., Director), Henry Ford Hospital, Detroit, Michigan.Journal of Investigative Dermatology, 1959