B lymphocyte antigen receptor signaling: initiation, amplification, and regulation
Open Access
- 1 October 2013
- journal article
- review article
- Published by H1 Connect in F1000Prime Reports
- Vol. 5 (40), 40
- https://doi.org/10.12703/p5-40
Abstract
B lymphocytes and their differentiated daughters are charged with responding to the myriad pathogens in our environment and production of protective antibodies. A sample of the protective antibody produced by each clone is utilized as a component of the cell’s antigen receptor (BCR). Transmembrane signals generated upon antigen binding to this receptor provide the primary directive for the cell’s subsequent response. In this report, we discuss recent progress and current controversy regarding B cell receptor signal initiation, transduction and regulation.Keywords
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