Intracellular Glutathione Detection Using MnO2-Nanosheet-Modified Upconversion Nanoparticles
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- 29 November 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 133 (50), 20168-20171
- https://doi.org/10.1021/ja2100774
Abstract
We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO(2)) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO(2) into Mn(2+). The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.Keywords
This publication has 72 references indexed in Scilit:
- Fluorescent and colorimetric probes for detection of thiolsChemical Society Reviews, 2010
- Design of Bis-spiropyran Ligands as Dipolar Molecule Receptors and Application to in Vivo Glutathione Fluorescent ProbesJournal of the American Chemical Society, 2009
- Determination of glutathione and glutathione disulfide in biological samples: An in-depth reviewJournal of Chromatography B, 2009
- A Highly Sensitive Fluorescence Probe for Fast Thiol‐Quantification Assay of Glutathione ReductaseAngewandte Chemie, 2009
- Quantum Dot-Based OFF/ON Probe for Detection of GlutathioneThe Journal of Physical Chemistry C, 2009
- Regulation of glutathione synthesisMolecular Aspects of Medicine, 2009
- Combinatorial Rosamine Library and Application to in Vivo Glutathione ProbeJournal of the American Chemical Society, 2007
- Glutathione in Cancer Biology and TherapyCritical Reviews in Clinical Laboratory Sciences, 2006
- Selective Detection of Cysteine and Glutathione Using Gold NanorodsJournal of the American Chemical Society, 2005
- The importance of glutathione in human diseaseBiomedicine & Pharmacotherapy, 2003