Bakuchiol: A Hepatoprotective Compound ofPsoralea corylifoliaon Tacrine-Induced Cytotoxicity in Hep G2 Cells

Abstract

Bioassay-guided fractionation of the H₂O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC₅₀ values of compounds 1 - 3 are 1.0, 47.0, 50.0 μg/ml, respectively. Silymarin as a positive control showed the EC₅₀ value with 5.0 μg/ml.