Methylphenidate-Induced Orofacial and Extremity Dyskinesia
- 1 June 2007
- journal article
- Published by Mary Ann Liebert Inc in Journal of Child and Adolescent Psychopharmacology
- Vol. 17 (3), 378-382
- https://doi.org/10.1089/cap.2006.0055
Abstract
In this paper, we report the case of a 6(1/2)-year-old male patient diagnosed with attention-deficit/hyperactivity disorder (ADHD) who developed orofacial and extremity dyskinesias immediately after methylphenidate treatment. The episode lasted 5 hours, peaking in intensity 2 hours after the medication was administered before gradually subsiding. Five hours after the methylphenidate was administered, the child became extremely irritated and aggressive, which lasted approximately 2 hours. The patient's general intelligence (IQ) was measured to be below the normal range. The potential relationship between methylphenidate intake and the development of dyskinesia calls into question different mechanisms involving drug-receptor interaction or individual drug sensitivity related to a lower IQ. Our case report has practical implications for physicians by raising their awareness of dyskinesia as a potential side effect of methylphenidate treatment.Keywords
This publication has 19 references indexed in Scilit:
- European clinical guidelines for hyperkinetic disorder ? first upgradeEuropean Child & Adolescent Psychiatry, 2004
- Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implicationsSynapse, 2001
- Stimulant drugsEuropean Child & Adolescent Psychiatry, 2000
- Efficacy, safety, and tolerance of the non-ergoline dopamine agonist pramipexole in the treatment of advanced Parkinson's disease: a double blind, placebo controlled, randomised, multicentre studyJournal of Neurology, Neurosurgery & Psychiatry, 1999
- Pharmacokinetics and Clinical Effectiveness of MethylphenidateClinical Pharmacokinetics, 1999
- Paroxysmal Kinesigenic Dystonia After Methylphenidate AdministrationJournal of Child Neurology, 1994
- Pemoline-Induced Abnormal Involuntary MovementsJournal of Clinical Psychopharmacology, 1989
- Methylphenidate‐induced choreaNeurology, 1978
- The effect of d‐amphetamine on choreiform movement disordersNeurology, 1974
- Dexedrine Dyskinesia: An Unusual latrogenic TicClinical Pediatrics, 1974