Monoclonal Antibodies to Three Non-glycosylated Antigens of Herpes Simplex Virus Type 2

Abstract

Summary The production and properties of three monoclonal antibodies, designated LP1, LP4 and AP2, directed against non-glycosylated polypeptides of herpes simplex virus type 2 are described. LP1 is specific for polypeptide VP16 and cross-reacts with HSV-1; LP4 reacts with the major DNA-binding protein and is type-specific. AP2 is directed against the major capsid antigen of HSV-1 and HSV-2.