A Novel One‐Pot Synthesis of 2‐Aryl‐4(3H)‐Quinazolinones Using Room Temperature Ionic Liquid as Reaction Medium as well as Promoter
- 1 January 2005
- journal article
- Published by Taylor & Francis Ltd in Synthetic Communications
- Vol. 35 (2), 231-241
- https://doi.org/10.1081/scc-200048433
Abstract
An efficient one‐pot synthesis of 2‐aryl‐4(3H)‐quinazolinones from 2‐amino benzamides and substituted benzoyl chlorides in a room temperature ionic liquid is described. Compared with the classical reaction conditions, this new synthetic method has the advantages of recyclability of ionic liquid, very good to excellent yields (78–92%), the absence of hazardous and expensive catalysts, and easy workup procedures giving rise to a process with minimum waste.Keywords
This publication has 30 references indexed in Scilit:
- Ionic liquids. Green solvents for the futurePublished by Walter de Gruyter GmbH ,2000
- Substituted Isoquinolines and Quinazolines as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor αJournal of Medicinal Chemistry, 1999
- Synthesis of 3‐amino‐2,4(1H,3H)‐quinazolinediones for testing as anticonvulsantsJournal of Heterocyclic Chemistry, 1984
- A simple one-step synthesis of 3-amino-2,4(1H,3H)quinazolinedionesJournal of Heterocyclic Chemistry, 1984
- Reactions of o‐aminonitriles with isocyanates. 2. A facile synthesis of imidazo[1,2‐c]quinazoline‐2,5‐(3H,6H)dioneJournal of Heterocyclic Chemistry, 1981
- Facile Syntheses of 2H-1,2,4-Benzothiadiazine 1,1-Dioxides and 4-Oxo-3,4-dihydroquinazolines from 2-Aminobenzenesulfonamide or 2-Aminobenzamide and Aldehydes in the Presence of Sodium Hydrogen SulfiteSynthesis, 1981
- 2‐Aryl‐4(3H)quinazolinonesJournal of Heterocyclic Chemistry, 1971
- Heterocyclic synthesis from o-aminonitriles. XXX. Synthesis of some diazasteroidsThe Journal of Organic Chemistry, 1968
- Alkaloids of Dichroa febrifuga. I. Isolation and Degradative StudiesJournal of the American Chemical Society, 1949
- Alkaloids of Dichroa Febrifuga Lour.Journal of the American Chemical Society, 1948