Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease
- 31 January 2012
- journal article
- Published by Elsevier BV in Neurobiology of Aging
- Vol. 33 (1), 197.e21-197.e32
- https://doi.org/10.1016/j.neurobiolaging.2010.06.014
Abstract
No abstract availableKeywords
Funding Information
- National Institutes of Health (AG16740, AG023012, AG024494)
- Blanchette Hooker Rockefeller Foundation
- American Health Assistance Foundation
- National Institutes of Health (F32 AG24031, F31-NS057867)
This publication has 72 references indexed in Scilit:
- CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial ActivationJournal of Neuroscience, 2009
- Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohortNeurology, 2009
- Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smokingAnnals of Neurology, 2009
- Protective effects of NSAIDs on the development of Alzheimer diseaseNeurology, 2008
- Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer miceBrain Research, 2008
- Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticityBrain, 2008
- Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor proteinProceedings of the National Academy of Sciences of the United States of America, 2008
- Mutations in amyloid precursor protein and presenilin‐1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid β‐peptide (1–42), H2O2 and kainic acid: implications for Alzheimer's diseaseJournal of Neurochemistry, 2006
- Activation of NADPH Oxidase in Alzheimer's Disease BrainsBiochemical and Biophysical Research Communications, 2000
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976