Reversal of fluoride induced cell injury through elimination of fluoride and consumption of diet rich in essential nutrients and antioxidants
- 1 January 2002
- book chapter
- other
- Published by Springer Science and Business Media LLC
- Vol. 234-235 (1-2), 335-340
- https://doi.org/10.1007/978-1-4615-1087-1_38
Abstract
The objective of the present communication is to address the issues concerning reversal of fluoride induced cell injury and disease (i.e. fluorosis) through the elimination of fluoride and consumption of a diet containing essential nutrients and antioxidants. Humans afflicted with fluorosis, as a result of consuming fluoride contaminated water or food, have been investigated. Hospital based diagnostic procedure for early detection of fluorosis, through retrieval of history, clinical complaints, testing of blood, urine and drinking water for fluoride using ion selective electrode technology, along with X-ray of the forearm have been carried out. Confirmed cases of fluorosis were introduced to an intervention protocol consisting of (1) provision of safe drinking water with fluoride levels less than 1 mg/L and (2) counselling on nutritional supplementation with focus on adequate intake of calcium, vitamins C, E and antioxidants. The patients were monitored at frequent intervals up to one year and the results are reported. With a standardized early diagnosis, elimination of fluoride intake and supplementation of a diet rich in essential nutrients and antioxidants, we have shown that the fluorosis can be reversed. (Mol Cell Biochem 234/235: 335-340, 2002) Key words reversal of fluorosis nutritional supplementation antioxidant therapyKeywords
This publication has 20 references indexed in Scilit:
- Toxic Effects of Chronic Fluoride Ingestion on the Upper Gastrointestinal TractJournal of Clinical Gastroenterology, 1994
- Fluoride as a possible aetiological factor in non-ulcer dyspepsiaJournal of Gastroenterology and Hepatology, 1992
- UNSUITABILITY OF WORLD HEALTH ORGANISATION GUIDELINES FOR FLUORIDE CONCENTRATIONS IN DRINKING WATER IN SENEGALThe Lancet, 1988
- The status of sulphated isomers of glycosaminoglycans in fluorosed human teethArchives of Oral Biology, 1988
- Fluoride Directly Stimulates Proliferation and Alkaline Phosphatase Activity of Bone-Forming CellsScience, 1983
- Cellular and histochemical characteristics of osteoid formed in experimental fluoride poisoningToxicology Letters, 1983
- In vivo Chondrogenesis and Histochemical Appearance of Dermatan Sulphate in Rabbit Cancellous BoneDifferentiation, 1982
- Characterization of glycosaminoglycans from normal and fluoride treated rabbit iliac crestBiochemical and Biophysical Research Communications, 1982
- Effects of fluoride on glycosaminoglycan of cancellous and cortical bone of rabbitsCellular and Molecular Life Sciences, 1981
- Effect of dietary calcium, vitamin C and protein in development of experimental skeletal fluorosis. I. Growth, serum chemistry, and changes in composition, and radiological appearance of bonesMetabolism, 1971