In vitro antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata
Open Access
- 6 August 2008
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 23 (1), 126-128
- https://doi.org/10.1002/ptr.2556
Abstract
Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania infantum. Compound TDR13011 (1,2-dihydroxy-6,8-dimethoxy-xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC50) of 4.6 µg/ml and 8 µg/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti-protozoal activity and these compounds could be chemically modified to obtain a more potent product. Copyright © 2008 John Wiley & Sons, Ltd.Keywords
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