Determination of pKa values of active pharmaceutical ingredients
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- 15 September 2007
- journal article
- Published by Elsevier BV in TrAC Trends in Analytical Chemistry
- Vol. 26 (11), 1043-1061
- https://doi.org/10.1016/j.trac.2007.09.004
Abstract
The acid dissociation constant is an important physicochemical parameter of a substance, and knowledge of it is of fundamental importance in a wide range of applications and research areas. We present a critical review of published methods and approaches for the determination of acid dissociation constants, with a special emphasis on the pKa values of active pharmaceutical ingredients.Keywords
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