Inhibition of Csn3 expression induces growth arrest and apoptosis of hepatocellular carcinoma cells
- 12 January 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cancer Chemotherapy and Pharmacology
- Vol. 69 (5), 1173-1180
- https://doi.org/10.1007/s00280-011-1810-x
Abstract
Csn3 (or CSN3) encodes the third subunit of an eight-subunit complex, the COP9 signalosome (CSN), which acts as a protein kinase and a deneddylase in mammalian cells. Previous studies have shown that Csn3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast and associated with the tumorigenesis process in osteosarcoma. However, its correlation with hepatocellular carcinoma (HCC) has not been explored yet.Keywords
This publication has 20 references indexed in Scilit:
- RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cellsCancer Gene Therapy, 2011
- Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancersJCI Insight, 2011
- p53 and its mutants in tumor cell migration and invasionThe Journal of cell biology, 2011
- Dynamics of nuclear receptor target gene regulationChromosoma, 2010
- Role of the MPN Subunits in COP9 Signalosome Assembly and Activity, and Their Regulatory Interaction withArabidopsisCullin3-Based E3 LigasesTHE PLANT CELL ONLINE, 2007
- The COP9 SignalosomeAnnual Review of Cell and Developmental Biology, 2003
- COP9 Signalosome Subunit 3 Is Essential for Maintenance of Cell Proliferation in the Mouse Embryonic EpiblastMolecular and Cellular Biology, 2003
- Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradationOncogene, 2003
- Evidence for FUS6 as a component of the nuclear-localized COP9 complex in Arabidopsis.THE PLANT CELL ONLINE, 1996
- Arabidopsis COP9 is a component of a novel signaling complex mediating light control of developmentCell, 1994