DNA methylation in genomic imprinting, development, and disease
Open Access
- 17 May 2001
- journal article
- review article
- Published by Wiley in The Journal of Pathology
- Vol. 195 (1), 97-110
- https://doi.org/10.1002/path.890
Abstract
Changes in DNA methylation profiles are common features of development and in a number of human diseases, such as cancer and imprinting disorders like Beckwith–Wiedemann and Prader–Willi/Angelman syndromes. This suggests that DNA methylation is required for proper gene regulation during development and in differentiated tissues and has clinical relevance. DNA methylation is also involved in X‐chromosome inactivation and the allele‐specific silencing of imprinted genes. This review describes possible mechanisms by which DNA methylation can regulate gene expression, using imprinted genes as examples. The molecular basis of methylation‐mediated gene regulation is related to changes in chromatin structure and appears to be similar for both imprinted and biallelically expressed genes. Copyright © 2001 John Wiley & Sons, Ltd.Keywords
This publication has 121 references indexed in Scilit:
- Alterations of H19 Imprinting and IGF2 Replication Timing Are Infrequent in Beckwith–Wiedemann SyndromeGenomics, 2000
- The Role of Histone Acetylation in the Allelic Expression of the Imprinted Human Insulin-like Growth Factor II GeneBiochemical and Biophysical Research Communications, 1998
- A 1-Mb Physical Map and PAC Contig of the Imprinted Domain in 11p15.5 That Contains TAPA1 and the BWSCR1/WT2 RegionGenomics, 1997
- Genomic imprinting and Wilms' tumorMedical and Pediatric Oncology, 1996
- Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN geneNature Genetics, 1996
- Binding of Histone H1 to DNA Is Indifferent to Methylation at CpG SequencesPublished by Elsevier BV ,1995
- Methylation at CpG Sequences Does Not Influence Histone H1 Binding to a Nucleosome Including a Xenopus borealis 5 S rRNA GenePublished by Elsevier BV ,1995
- Allele specificity of DNA replication timing in the Angelman/Prader–Willi syndrome imprinted chromosomal regionNature Genetics, 1994
- Identification of a mammalian protein that binds specifically to DNA containing methylated CpGsCell, 1989
- Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cellsJournal of Molecular Biology, 1988