Influence of weight loss on outcomes in patients with head and neck cancer undergoing concomitant chemoradiotherapy
- 20 December 2007
- journal article
- research article
- Published by Wiley in Head & Neck
- Vol. 30 (4), 503-508
- https://doi.org/10.1002/hed.20737
Abstract
Background. The purpose of this study was to determine the influence of weight loss on outcome in patients with head and neck cancer undergoing concomitant chemoradiotherapy (CCRT): treatment interruption, infections, mortality, and hospital readmission rate. Methods. Forty patients with head and neck cancer were enrolled. All patients were counseled to follow a nutritional program during CCRT. Body weight was evaluated at baseline, at the end, and 30 days after radiochemotherapy. Results. Ninety percent of compliant patients with nutritional program maintained body weight (mean, 1 ± 2.4 kg) and 100% of noncompliant patients continued to lose weight (mean, −9 ± 4 kg; p < .001). A reduction greater than 20% of prediagnosis weight significantly correlated with treatment interruption (p = .003), infections (p = .002), early mortality (p = .011), hospital readmission rate (p = .001), and survival (log-rank test: z = −2.722, p = .006). Conclusion. In patients with head and neck cancer undergoing CCRT, the early nutritional management reduces weight loss and improve outcome. © 2007 Wiley Periodicals, Inc. Head Neck, 2008Keywords
This publication has 20 references indexed in Scilit:
- Early nutritional support and quality of life (QoL): Primary end point in cancer patients during chemo- and/or radiotherapyJournal of Clinical Oncology, 2005
- Functional Outcomes Following Chemoradiotherapy for Head and Neck CancerOtolaryngology -- Head and Neck Surgery, 2004
- Does nutrition influence quality of life in cancer patients undergoing radiotherapy?Radiotherapy and Oncology, 2003
- Predictors of Weight Loss During Radiation TherapyOtolaryngology -- Head and Neck Surgery, 2001
- Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?European Journal of Cancer, 1998
- The effect of interruptions and prolonged treatment time in radiotherapy for nasopharyngeal carcinomaInternational Journal of Radiation Oncology*Biology*Physics, 1997
- Does tumor control decrease by prolonging overall treatment time or interrupting treatment in laryngeal cancer?Radiotherapy and Oncology, 1995
- Long-term treatment results of postoperative radiation therapy for advanced stage oropharyngeal carcinomaCancer, 1992
- interruptions adversely affect local control and survival with hyperfractionated radiation therapy of carcinomas of the upper respiratory and digestive tracts new evidence for accelerated proliferation from radiation therapy oncology group protocol 8313Cancer, 1992
- Combined chemotherapy and radiation therapy in advanced inoperable squamous cell carcinoma of the head and neck. The final report of a randomized trialCancer, 1991