Distribution of orally administered β-carotene among lipoproteins in healthy men
Open Access
- 1 July 1992
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 56 (1), 128-135
- https://doi.org/10.1093/ajcn/56.1.128
Abstract
Plasma and lipoprotein concentrations of β-carotene (BC) were measured in men for 10 d after an oral dose of BC (120 mg) (experimental subjects, n = 11 ) or no BC (control subjects, n = 5). Lipoproteins were separated by sequential ultracentrifugation and BC was measured by HPLC. Plasma and lipoprotein BC concentrations in control subjects were steady. In experimental subjects, plasma BC content increased by 6 h postdosing (P < 0.015), peaked at 24 h (P < 0.05), and returned to baseline by 7 d. Maintenance of plasma BC concentrations suggests homeostatic control. Of the 11 experimental subjects, only 4 had a plasma response. Early increases in the BC content of chylomicrons, very-low-density lipoproteins, and intermediate-density lipoproteins were associated with decreases in the BC content of low-density lipoproteins and high-density lipoproteins. Intestinal input accounts for early rises in circulating BC concentrations whereas hepatic secretion is the source of later increases. Among all of the lipoproteins, transfer of BC may occur.This publication has 31 references indexed in Scilit:
- Normal serum response to oral beta-carotene in humans.Journal of the American College of Nutrition, 1989
- The effect of different levels of dietary ß‐carotene on DMBA‐induced salivary gland tumorsNutrition and Cancer, 1987
- In Vitro transfer of chylomicron retinol and retinyl estersBiochemical and Biophysical Research Communications, 1983
- Relative value of carotenoids as precursors of vitamin AProceedings of the Nutrition Society, 1983
- Antitumor Activity of β-Carotene, Canthaxanthin and PhytoeneOncology, 1982
- Human chylomicron apolipoprotein metabolismBiochemical and Biophysical Research Communications, 1978
- On the metabolic conversion of human plasma very low density lipoprotein to low density lipoproteinBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973
- The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observationsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
- The intestinal absorption and metabolism of vitamin A and beta-carotene in man.JCI Insight, 1966
- DENSITOMETRIC ANALYSIS OF BODY COMPOSITION: REVISION OF SOME QUANTITATIVE ASSUMPTIONS*Annals of the New York Academy of Sciences, 1963