Exocrine Pancreatic Function in the Early Phase of Human Acute Pancreatitis
- 1 January 1995
- journal article
- research article
- Published by Informa UK Limited in Scandinavian Journal of Gastroenterology
- Vol. 30 (2), 186-191
- https://doi.org/10.3109/00365529509093260
Abstract
Background: Little is known about exocrine pancreatic function during human acute pancreatitis. We aimed to evaluate interdigestive exocrine pancreatic secretion and pancreatic polypeptide (PP) release during the early phase of acute pancreatitis in humans. Methods: Eight patients with acute pancreatitis (six biliary, one alcoholic, and one idiopathic acute pancreatitis) were studied within 72 h from the onset of symptoms. Four patients had necrotizing and four had edematous acute pancreatitis. Normal values were obtained from 26 normal subjects matched by sex and age. Interdigestive pancreatic secretion was studied by a duodenal intubation perfusion technique. Enzyme output was calculated for consecutive 15-min periods over 3-4 h and expressed as units per hour within a secretion cycle and units per hour around a secretion peak. Plasma PP concentrations were measured by radioimmunoassay in 15-min intervals. Results: All variables studied were similar in patients with acute pancreatitis and in controls. PP release in acute pancreatitis was maintained in a normal cyclical pattern closely related to the secretory cycles. Conclusions: Interdigestive exocrine pancreatic secretion in the early phase of mild to moderate acute pancreatitis in humans remains within the normal range. This finding provides a rational basis for early therapeutic inhibition of pancreatic secretion in human acute pancreatitis.Keywords
This publication has 12 references indexed in Scilit:
- Somatostatin in the treatment of acute pancreatitis: a prospective randomised controlled trial.Gut, 1989
- Follow-Up After Acute Pancreatitis: Morphology and FunctionPublished by Springer Science and Business Media LLC ,1987
- Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis.JCI Insight, 1986
- Long-Term Outcome of Acute Necrohemorrhagic PancreatitisDigestion, 1984
- Functional Recovery of the Exocrine Pancreas after Acute PancreatitisScandinavian Journal of Gastroenterology, 1983
- Exocrine Pancreatic Secretion in Acute Experimental PancreatitisDigestion, 1982
- Influence of Hormonal Stimulation by Caerulein on Acute Experimental Pancreatitis in the RatEuropean Surgical Research, 1981
- A Double-blind Trial of Synthetic Salmon Calcitonin in the Treatment of Acute PancreatitisScandinavian Journal of Gastroenterology, 1979
- Course and spontaneous regression of acute pancreatitis in the ratVirchows Archiv, 1979
- Is nasogastric suction necessary in acute pancreatitis?BMJ, 1978