Lack of oral tolerance in C3H/HeJ mice.
Open Access
- 1 February 1982
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 155 (2), 605-610
- https://doi.org/10.1084/jem.155.2.605
Abstract
Daily gastric intubation of lipopolysaccharide (LPS)-responsive C3H/HeN, BALB/c, and Swiss mice with SRBC for 2 wk resulted in oral tolerance, whereas similarly treated LPS-nonresponsive C3H/HeJ mice gave splenic anti-SRBC PFC responses, including the IgA isotype, after systemic challenge with antigen. Oral tolerance in LPS-responsive C3H/HeN mice was due to T suppressor (Ts) cells because significant Ts cell activity was demonstrated in both Peyer's patches (PP) and spleens of these animals. On the other hand, T cells from PP and spleens of identically treated C3H/HeJ mice exhibited mainly T helper cell activity. Prior treatment of PP or spleen cell preparations from tolerant C3H/HeN mice with anti-Lyt-2.1 resulted in good in vitro anti-SRBC PFC responses, especially IgA isotype responses in PP cell cultures. These results indicate that oral administration of a thymic-dependent antigen (SRBC) to LPS-responsive mice induced a Ts cell population in PP, which, after migration to peripheral lymphoid tissue (e.g., spleen), suppressed responses to systemically administered antigen. LPS-nonresponsive mice lack this Ts cell pathway and continually respond to oral administration of antigen.Keywords
This publication has 11 references indexed in Scilit:
- Immunobiology of Dental Caries: Microbial Aspects and Local ImmunityAnnual Review of Microbiology, 1981
- Systemic tolerance and secretory immunity after oral immunization.The Journal of Experimental Medicine, 1980
- Two distinct antigen-specific suppressor factors induced by the oral administration of antigen.The Journal of Experimental Medicine, 1980
- Cellular basis for elevated IgA responses in C3H/HeJ mice.The Journal of Immunology, 1980
- ORAL TOLERANCETransplantation, 1980
- Cellular requirements for lipopolysaccharide adjuvanticity. A role for both T lymphocytes and macrophages for in vitro responses to particulate antigens.The Journal of Experimental Medicine, 1979
- Immunologic suppression after oral administration of antigen. I. Specific suppressor cells formed in rat Peyer's patches after oral administration of sheep erythrocytes and their systemic migration.1978
- The Qa-1 antigenic system. Relation of Qa-1 phenotypes to lymphocyte sets, mitogen responses, and immune functions.The Journal of Experimental Medicine, 1978
- Effects of antigen-feeding on intestinal and systemic immune responses: III. Antigen-specific serum-mediated suppression of humoral antibody responses after antigen feedingCellular Immunology, 1978
- A mechanism for the induction of immunological tolerance by antigen feeding: antigen-antibody complexes.The Journal of Experimental Medicine, 1975