Outcome of pregnancies complicated by severe ovarian hyperstimulation syndrome (OHSS): a follow-up beyond the second trimester
Open Access
- 1 April 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 20 (4), 910-914
- https://doi.org/10.1093/humrep/deh713
Abstract
The main aim of this study was to assess the obstetric complications for those pregnancies that are complicated by ovarian hyperstimulation syndrome (OHSS) and continue beyond the first trimester. We checked also for other related serious events that occurred during the first trimester. METHODS: We included only patients whose pregnancies continued beyond the first trimester and compared them with IVF-treated patients displaying moderate ovarian response. RESULTS: We studied 165 patients with OHSS (101 singletons and 64 twins) and 156 IVF control patients (85 singletons and 71 twins). Two serious complications, gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH), were noted in both groups. However, the incidence of these two complications did not differ significantly between the groups. In the OHSS group, GDM presented with an incidence of 9.9% for singletons and 9.4% for twins, and 12.9% and 7.0%, respectively, for the control group. PIH presented as 6.9% for singletons and 10.9% for twins in the OHSS group, and 8.2% and 7.0%, respectively, for the control groups. During the first trimester laparoscopies for suspected ovarian torsion were performed in 13 patients, and in 10 patients the diagnosis were confirmed. CONCLUSIONS: Although patients with OHSS-complicated pregnancies previously reported a relatively high risk of GDM and PIH, the occurrence rates do not differ from a matched control group of normally responding patients who conceived after IVF.Keywords
This publication has 16 references indexed in Scilit:
- Adnexal torsion after gonadotrophin ovulation induction for IVF or ICSI and its conservative treatmentArchiv für Gynäkologie, 2002
- Metabolic characteristics of women who developed ovarian hyperstimulation syndrome.Human Reproduction, 2002
- Is ovarian hyperstimulation syndrome associated with a poor obstetric outcome?BJOG: An International Journal of Obstetrics and Gynaecology, 2000
- Obstetric outcome of in vitro fertilized pregnancies complicated by severe ovarian hyperstimulation syndrome: a multicenter studyFertility and Sterility, 1998
- Obstetric outcome of singleton pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneouslyFertility and Sterility, 1998
- The pathophysiology of ovarian hyperstimulation syndrome--views and ideasHuman Reproduction, 1997
- Enhancement by endothelin‐1 of microvascular permeability via the activation of ETA receptorsBritish Journal of Pharmacology, 1993
- High levels of immunoreactive endothelin-1 in human follicular fluidsHuman Reproduction, 1993
- Adnexal torsion of hyperstimulated ovaries in pregnancies after gonadotropin therapyFertility and Sterility, 1990
- Ovarian Hyperstimulation SyndromeObstetrical & Gynecological Survey, 1989