Heterocycle Synthesis via Direct C–H/N–H Coupling
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- 29 December 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 134 (1), 7-10
- https://doi.org/10.1021/ja210959p
Abstract
A method for five- and six-membered heterocycle formation by palladium-catalyzed C–H/N–H coupling is presented. The method employs a picolinamide directing group, PhI(OAc)2 oxidant, and toluene solvent at 80–120 °C. Cyclization is effective for sp2 as well as aliphatic and benzylic sp3 C–H bonds.Keywords
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