Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood
- 4 February 2016
- journal article
- research article
- Published by Wiley in Pediatric Obesity
- Vol. 12 (1), 48-57
- https://doi.org/10.1111/ijpo.12106
Abstract
Background Prenatal exposure to traffic pollution has been associated with faster infant weight gain, but implications for cardiometabolic health in later childhood are unknown. Methods Among 1418 children in Project Viva, a Boston‐area pre‐birth cohort, we assessed anthropometric and biochemical parameters of cardiometabolic health in early (median age 3.3 years) and mid‐ (median age 7.7 years) childhood. We used spatiotemporal models to estimate prenatal and early life residential PM2.5 and black carbon exposure as well as traffic density and roadway proximity. We performed linear regression analyses adjusted for sociodemographics. Results Children whose mothers lived close to a major roadway at the time of delivery had higher markers of adverse cardiometabolic risk in early and mid‐childhood. For example, total fat mass was 2.1 kg (95%CI: 0.8, 3.5) higher in mid‐childhood for children of mothers who lived 2.5 exposure during the year prior was paradoxically associated with improved cardiometabolic profile. Conclusions Infants whose mothers lived close to a major roadway at the time of delivery may be at later risk for adverse cardiometabolic health.Keywords
Funding Information
- National Institutes of Health (K24HD069408, R37HD034568, P30DK092924, P30ES000002, P01ES009825, R01AI102960, K12DK094721, K23ES024803)
- Environmental Protection Agency (RD83479801\)
- Harvard School of Public Health
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