Background: COPD is one of the leading causes of death. The lack of an accurate prognostic tool that can accurately predict in-hospital mortality and help clinicians triage patients to the appropriate level of care is still challenging. This study aims to: 1/ To evaluate the parameters of DECAF Score, 2/ To assess the prognosis for in-hospital mortality of acute exacerbation of COPD. Materials and methods: 68 male patients with the diagnosis of acute exacerbation of COPD admitted to the hospital. Admission clinical data and inhospital death rates were recorded. The prognostic value of DECAF score were assessed by the area under the receiver operator characteristic (AUROC) curve. Results: DECAF score included 5 factors: eosinopenia (26.5%), consolidation (10.3%), acidemia (14.7%), atrial fibrilation (5.9%), eMRCD 5a (10.3%), eMRCD 5b (2.9%). The DECAF AUROC curve for in-hospital mortality was 0.884 (95%CI: 0.783 - 0.949) with sensitivity 77.8% (95%CI: 40.1 - 96.5) and specificity 93.2% (95%CI: 83.5 - 98.1). Conclusion: DECAF is a simple but powerful predictor of in-hospital mortality for acute exacerbation of COPD. Key words: DECAF score, acute exacerbation of COPD, mortality, prognostic value