Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433
Top Cited Papers
- 8 October 2018
- journal article
- review article
- Published by American Chemical Society (ACS) in Chemical Reviews
- Vol. 119 (2), 797-828
- https://doi.org/10.1021/acs.chemrev.8b00211
Abstract
Transition metal complexes are of increasing interest as photosensitizers in photodynamic therapy (PDT) and, more recently, for photochemotherapy (PCT). In recent years, Ru(II) polypyridyl complexes have emerged as promising systems for both PDT and PCT. Their rich photochemical and photophysical properties derive from a variety of excited-state electronic configurations accessible with visible and near-infrared light, and these properties can be exploited for both energy- and electron-transfer processes that can yield highly potent oxygen-dependent and/or oxygen-independent photobiological activity. Selected examples highlight the use of rational design in coordination chemistry to control the lowest-energy triplet excited-state configurations for eliciting a particular type of photoreactivity for PDT and/or PCT effects. These principles are also discussed in the context of the development of TLD1433, the first Ru(II)-based photosensitizer for PDT to enter a human clinical trial. The design of TLD1433 arose from a tumor-centered approach, as part of a complete PDT package that includes the light component and the protocol for treating non-muscle invasive bladder cancer. Briefly, this review summarizes the challenges to bringing PDT into mainstream cancer therapy. It considers the chemical and photophysical solutions that transition metal complexes offer, and it puts into context the multidisciplinary effort needed to bring a new drug to clinical trial.Funding Information
- Canadian Institutes of Health Research
- National Cancer Institute (R01CA222227)
- Welch Foundation (E-621)
- Beatrice Hunter Cancer Research Institute
- Nova Scotia Research Innovation Trust
- Basic Energy Sciences (DE-FG02-07ER15888)
- Canada Foundation for Innovation
- Dalhousie Medical Research Foundation
- Acadia University
- Natural Sciences and Engineering Research Council of Canada
- Theralase Technologies Inc.
This publication has 157 references indexed in Scilit:
- Photoactivatable metal complexes: from theory to applications in biotechnology and medicinePhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2013
- A Comprehensive Tutorial onIn VitroCharacterization of New Photosensitizers for Photodynamic Antitumor Therapy and Photodynamic Inactivation of MicroorganismsBioMed Research International, 2013
- Dye Sensitizers for Photodynamic TherapyMaterials, 2013
- Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and OptimizationChemical Reviews, 2010
- Enhancement of anti-tumor immunity by photodynamic therapyImmunologic Research, 2009
- Application of Metal Coordination Chemistry To Explore and Manipulate Cell BiologyChemical Reviews, 2009
- Photodynamic Therapy and the Development of Metal-Based PhotosensitisersMetal-Based Drugs, 2008
- A potent cytotoxic photoactivated platinum complexProceedings of the National Academy of Sciences of the United States of America, 2007
- Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activationProceedings of the National Academy of Sciences of the United States of America, 2007
- Photodynamic therapy and anti-tumour immunityNature Reviews Cancer, 2006