Dietary Isothiocyanates, Glutathione S-Transferase M1 (GSTM1), and Lung Cancer Risk in African Americans and Caucasians from Los Angeles County, California
- 25 June 2009
- journal article
- research article
- Published by Informa UK Limited in Nutrition and Cancer
- Vol. 61 (4), 492-499
- https://doi.org/10.1080/01635580902752270
Abstract
Isothiocyanates, found in cruciferous vegetables, are anticarcinogenic. Racial differences in smoking do not fully account for the African-American excess lung cancer incidence. African Americans consume more cruciferous vegetables than U.S. Whites. Impact on lung cancer risk is unknown. The glutathione S transferase M1 (GSTM1) gene promotes urinary isothiocyanate excretion. We evaluated dietary isothiocyanates and lung cancer using a population-based case-control study of 933 African Americans and Caucasians (non-Hispanic U.S. White) from Los Angeles County, California (311 cases; 622 controls). Broccoli, cauliflower, greens, and cabbage food-frequency variables represented isothiocyanates. Isothiocyanates were protective for lung cancer risk. Adjusted odds ratio (OR) for the uppermost quartile > 80 μ mol isothiocyanates/wk, compared to lowest, was 0.65 [95% confidence interval (CI) = 0.41–1.00, trend P = 0.02]. Association was stronger among subjects with homozygous deletion of GSTM1 (OR = 0.52, 95% CI = 0.31–0.86) than subjects with at least one GSTM1 copy (OR = 0.77, 95% CI = 0.49–1.21). The difference was not statistically significant (P = 0.16). Despite African Americans consuming more cruciferous vegetables, the isothiocyanate association did not vary by race (P = 0.52). Reduced lung cancer risk with higher isothiocyanate intake may be slightly stronger among subjects with deletion of GSTM1.Keywords
This publication has 46 references indexed in Scilit:
- Interactions between GSTM1, GSTT1 and GSTP1 polymorphisms and smoking and intake of fruit and vegetables in relation to lung cancerLung Cancer, 2007
- Phenethyl Isothiocyanate and Sulforaphane and their N-Acetylcysteine Conjugates Inhibit Malignant Progression of Lung Adenomas Induced by Tobacco Carcinogens in A/J MiceCancer Research, 2005
- A regional food-frequency questionnaire for the US Mississippi DeltaPublic Health Nutrition, 2005
- Fruits and vegetables and lung cancer: Findings from the European prospective investigation into cancer and nutritionInternational Journal of Cancer, 2003
- Fruits, vegetables and lung cancer: A pooled analysis of cohort studiesInternational Journal of Cancer, 2003
- Lung Cancer Risk in White and Black AmericansAnnals of Epidemiology, 2003
- Total Isothiocyanate Contents in Cooked Vegetables Frequently Consumed in SingaporeJournal of Agricultural and Food Chemistry, 1998
- Genetic polymorphism of CYP2D6 and lung cancer risk in African- Americans and Caucasians in Los Angeles CountyCarcinogenesis: Integrative Cancer Research, 1997
- Effect of Brussels sprouts on oxidative DNA-damage in manCancer Letters, 1997
- Case‐control assessment of diet and lung cancer risk in African Americans and Mexican AmericansNutrition and Cancer, 1997