Role of DNA topoisomerase I in the replication of herpes simplex virus type 2
- 1 March 1990
- journal article
- research article
- Published by Springer Science and Business Media LLC in Archiv für die gesamte Virusforschung
- Vol. 110 (1-2), 121-127
- https://doi.org/10.1007/bf01310708
Abstract
Camptothecin (CPT), a specific inhibitor of DNA topoisomerase I, effectively inhibited the replication of herpes simplex virus type 2 (HSV-2). CPT was found to reduce the level of immediate early viral mRNA in a dose-response manner. On the other hand, we could not find any evidence that a novel DNA topoisomerase I was induced in HSV-2-infected cells. Our observations suggest that host cell DNA topoisomerase I is involved in the replication of HSV-2.Keywords
This publication has 14 references indexed in Scilit:
- The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1Journal of General Virology, 1988
- Mechanism of inhibition of herpes simplex virus replication by Δ7-prostaglandin A1 and Δ12-prostaglandin J2Biochemical and Biophysical Research Communications, 1987
- Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.Proceedings of the National Academy of Sciences of the United States of America, 1987
- Studies on DNA Topoisomerases I and II in Herpes Simplex Virus Type 2-infected CellsJournal of General Virology, 1987
- Recent studies of DNA topoisomerasesBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1987
- Effects of the Epipodophyllotoxin VP-16-213 on Herpes Simplex Virus Type 2 ReplicationJournal of General Virology, 1987
- Association of Type I DNA Topoisomerase with Herpes Simplex VirusJournal of General Virology, 1985
- A DNA topoisomerase activity copurifies with the DNA polymerase induced by herpes simplex virusBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1983
- Characterization of human cytomegalovirus-induced DNA polymerase and the associated 3′-to−5′, exonucleaseVirology, 1983
- Aphidicolin inhibits eukaryotic DNA replication and repair — Implications for involvement of DNA polymerase α in both processesBiochemical and Biophysical Research Communications, 1979