Triglyceride-lowering agents: fibrates and nicotinic acid

Abstract

The evidence that hypertriglyceridemia is a risk factor for the premature development of coronary artery disease in certain populations remains strong. The two most effective classes of triglyceride-lowering drugs are nicotinic acid and its derivatives and the fibrates. The present review discusses recent work in which the effect of these drugs on the concentrations and metabolism of lipoproteins in human patients has been evaluated.