The evolution of white matter microstructural changes after mild traumatic brain injury: A longitudinal DTI and NODDI study
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Open Access
- 1 August 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 6 (32), eaaz6892
- https://doi.org/10.1126/sciadv.aaz6892
Abstract
Neuroimaging biomarkers that can detect white matter (WM) pathology after mild traumatic brain injury (mTBI) and predict long-term outcome are needed to improve care and develop therapies. We used diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) to investigate WM microstructure cross-sectionally and longitudinally after mTBI and correlate these with neuropsychological performance. Cross-sectionally, early decreases of fractional anisotropy and increases of mean diffusivity corresponded to WM regions with elevated free water fraction on NODDI. This elevated free water was more extensive in the patient subgroup reporting more early postconcussive symptoms. The longer-term longitudinal WM changes consisted of declining neurite density on NODDI, suggesting axonal degeneration from diffuse axonal injury for which NODDI is more sensitive than DTI. Therefore, NODDI is a more sensitive and specific biomarker than DTI for WM microstructural changes due to mTBI that merits further study for mTBI diagnosis, prognosis, and treatment monitoring.Funding Information
- U.S. National Institutes of Health, National Institute of Neurological Disorders and Stroke (U01 NS086090)
- U.S. Department of Defense TBI Endpoints Development (TED) Initiative (W81XWH-14-2-0176)
- OneMind
- NeuroTrauma Sciences LLC
This publication has 47 references indexed in Scilit:
- Abnormal white matter microstructure in children with sensory processing disordersNeuroImage: Clinical, 2013
- Neuroimaging Biomarkers in Mild Traumatic Brain Injury (mTBI)Neuropsychology Review, 2013
- Traumatic Brain InjuryJama-Journal Of The American Medical Association, 2013
- Axon diameter mapping in the presence of orientation dispersion with diffusion MRINeuroImage, 2011
- Twenty‐five pitfalls in the analysis of diffusion MRI dataNMR in Biomedicine, 2010
- Diffusion Tensor MR Imaging and Fiber Tractography: Theoretic UnderpinningsAmerican Journal Of Neuroradiology, 2008
- Principles of Diffusion Tensor Imaging and Its Applications to Basic Neuroscience ResearchNeuron, 2006
- Diffusion‐tensor MRI: theory, experimental design and data analysis – a technical reviewNMR in Biomedicine, 2002
- Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain ImagesNeuroImage, 2002
- Fast robust automated brain extractionHuman Brain Mapping, 2002