Colostrum-derived B and T cells as an extra-lymphoid compartment of effector cell populations in humans
- 19 October 2012
- journal article
- research article
- Published by Informa UK Limited in The Journal of Maternal-Fetal & Neonatal Medicine
- Vol. 26 (2), 137-142
- https://doi.org/10.3109/14767058.2012.733744
Abstract
Colostrum contains cellular components that convey immunological protection to offspring. In the present study the main subsets of lymphocytes present in colostrum and in peripheral blood of healthy screened mothers were compared through the evaluation of >15 different flow cytometry markers. Colostrum and peripheral blood samples were collected within 3 days after full-term delivery. Flow cytometry assays and laboratory tests were performed soon after collection. Among B cells, percentages of CD19+CD5+ cells, pertaining to natural immunity system, were significantly higher in colostrum than in peripheral blood (33 vs. 5%, p = 0.047). CD4+ T cells, effector cells (CD45RA+/CD27–) and effector memory cells (CD45RA–/CD27–) were significantly higher in colostrum (p < 0.001) than in peripheral blood, as well as activated CD4+ T cells (HLA–DR+) (36% vs. 6% p = 0.0022) and CD4+ terminally differentiated effector T cells (CD57+) (p < 0.001). With regards to CD8+ T cells, a comparable significant increase in effector (p < 0.02) and effector memory cells (p < 0.001) was also observed. Moreover, an increased surface expression of HLA-DR and CD57 (p < 0.001) on CD8+ T cells in colostrum was detected. Colostrum contains a different distribution of lymphocyte subsets with respect to peripheral blood from mothers, confirming the observation that lymphocytes probably migrate in milk in a selective way. Colostrum T and B lymphocytes appear to be enriched with subsets possessing effector functions or belonging to the innate immune system, what could transfer a prompt line of defence to offspring.Keywords
This publication has 32 references indexed in Scilit:
- Breast Milk as the Gold Standard for Protective NutrientsThe Journal of Pediatrics, 2010
- The Immunological Components of Human MilkAdvances in Food and Nutrition Research, 2008
- Healthcare-associated infections in neonatal units: lessons from contrasting worldsJournal of Hospital Infection, 2007
- Development of the Infant Intestine: Implications for Nutrition SupportNutrition in Clinical Practice, 2007
- The British Journal of Nutrition, an international journal that continues to developBritish Journal of Nutrition, 2006
- The Immunological Components of Human Milk and Their Effect on Immune Development in Infants ,Journal of Nutrition, 2005
- Cytokines in Breast Milk from Allergic and Nonallergic MothersPediatric Research, 2000
- The immune system of human milkThe Pediatric Infectious Disease Journal, 1993
- A Comparative Study of Cells and Anti-microbial Proteins in Colostrum of Mothers Delivering Pre- and Full-term BabiesJournal of Tropical Pediatrics, 1991
- Cellular Composition Including Lymphocyte Subsets in Preterm and Full Term Human Colostrum and MilkActa Paediatrica, 1991