Association between Primary Hyperparathyroidism and Increased Body Weight: A Meta-Analysis
Open Access
- 1 March 2005
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 90 (3), 1525-1530
- https://doi.org/10.1210/jc.2004-1891
Abstract
Although primary hyperparathyroidism is frequently asymptomatic, it has been associated with an increased prevalence of hypertension, insulin resistance, dyslipidemia, cardiovascular mortality, and cancer. Previously we reported that patients with primary hyperparathyroidism are heavier than age-matched controls. Increased body weight could contribute to the association between primary hyperparathyroidism and these extraskeletal complications. We searched MEDLINE for English language studies published between 1975 and 2003 that reported body weight or body mass index in subjects with primary hyperparathyroidism and a healthy age- and sex-comparable eucalcemic control group. Seventeen eligible studies were identified. Subjects with primary hyperparathyroidism were 3.34 kg (95% confidence interval, 1.97–4.71; P < 0.00001) heavier than controls in 13 studies reporting body weight. In four studies reporting body mass index, subjects with primary hyperparathyroidism had an increased body mass index of 1.13 kg/m2 (−0.29 to 2.55; P = 0.12) compared with controls. Standard mean difference analysis showed that subjects with primary hyperparathyroidism had an increased weight or body mass index of 0.3 sd (0.19–0.40; P < 0.00001) compared with controls. We conclude that patients with primary hyperparathyroidism are heavier than their eucalcemic peers, and that increased body weight may contribute to the reported associations between primary hyperparathyroidism and some extraskeletal complications.Keywords
This publication has 64 references indexed in Scilit:
- Increased Mortality in Patients Hospitalized with Primary Hyperparathyroidism during the Period 1977–1993 in DenmarkWorld Journal of Surgery, 2003
- Cardiovascular Events before and after Surgery for Primary HyperparathyroidismWorld Journal of Surgery, 2003
- Treatment of Primary HyperparathyroidismThe New England Journal of Medicine, 1999
- A 10-Year Prospective Study of Primary Hyperparathyroidism with or without Parathyroid SurgeryThe New England Journal of Medicine, 1999
- Cardiovascular risk factors in primary hyperparathyroidism: a 15‐year follow‐up of operated and unoperated casesJournal of Internal Medicine, 1991
- Premature death in patients operated on for primary hyperparathyroidismWorld Journal of Surgery, 1990
- INCREASED RISK OF MALIGNANT DISEASES AFTER SURGERY FOR PRIMARY HYPERPARATHYROIDISMAmerican Journal of Epidemiology, 1988
- Prevalence of hypercalcaemia in a health survey: a 14‐year follow‐up study of serum calcium valuesEuropean Journal of Clinical Investigation, 1988
- SURVIVAL AND RENAL FUNCTION IN UNTREATED HYPERCALCAEMIAThe Lancet, 1987
- Diabetes mellitus, glucose tolerance and insulin response to glucose in patients with primary hyperparathyroidism before and after parathyroidectomyEuropean Journal of Clinical Investigation, 1983