The need and opportunity for donation after circulatory death worldwide
- 1 February 2018
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Organ Transplantation
- Vol. 23 (1), 136-141
- https://doi.org/10.1097/mot.0000000000000486
Abstract
The global shortage of organ donors will not be resolved solely by relying on deceased donation following a brain death determination (DBD). Expansion of deceased donation after circulatory death (DCD) will be needed to address the shortfall of organs for transplantation. Approximately 120 000 organ transplants are performed each year; however, the WHO estimates that this number of transplants only resolves 10% of the annual worldwide transplant need. The report addresses the opportunity of DCD expansion by evaluating the DCD potential that is not being realized, the utility of DCD enabling DBD to emerge in some clinical situations, by the effectiveness of a donor registry in achieving DCD, and by the current clinical research of heart, lung, and liver transplantation from DCD. The future of deceased donation must include DCD and ex-vivo organ repair if the organ shortage is to be reconciled even partially to the ongoing demand. Although the religious and legal impediments have been overcome to determine brain death, the possibility of DCD has not been addressed. A program of DCD is feasible in all countries with transplantation services. The excellent results following kidney and lung transplantation suggest opportunities of heart and liver transplantation should be the focus of needed DCD accomplishment in the near future.Keywords
This publication has 13 references indexed in Scilit:
- Ex-vivo lung perfusionCurrent Opinion in Organ Transplantation, 2017
- Improving the Outcomes of Organs Obtained From Controlled Donation After Circulatory Death Donors Using Abdominal Normothermic Regional PerfusionAmerican Journal of Transplantation, 2017
- Changing Patterns of Organ DonationTransplantation, 2016
- Normothermic Ex Vivo Perfusion Provides Superior Organ Preservation and Enables Viability Assessment of Hearts From DCD DonorsAmerican Journal of Transplantation, 2015
- An International Comparison of the Effect of Policy Shifts to Organ Donation following Cardiocirculatory Death (DCD) on Donation Rates after Brain Death (DBD) and Transplantation RatesPLOS ONE, 2013
- Current situation of donation after circulatory death in European countriesTransplant International, 2011
- The critical pathway for deceased donation: reportable uniformity in the approach to deceased donationTransplant International, 2011
- Kidneys from Donors after Cardiac Death Provide Survival BenefitJournal of the American Society of Nephrology, 2010
- Report of a National Conference on Donation after Cardiac DeathAmerican Journal of Transplantation, 2006
- The Institute of Medicine's Report on Non-Heart-Beating Organ TransplantationKennedy Institute of Ethics Journal, 1998