Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivative
- 1 April 2006
- journal article
- research article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery: Spine
- Vol. 4 (4), 310-318
- https://doi.org/10.3171/spi.2006.4.4.310
Abstract
Object Spinal cord injury (SCI) is a devastating clinical syndrome for which no truly efficacious therapy has yet been identified. In preclinical studies, erythropoietin (EPO) and its nonerythropoietic derivatives asialoEPO and carbamylated EPO have markedly improved functional outcome when administered after compressive SCI. However, an optimum treatment paradigm is currently unknown. Because the uninjured spinal cord expresses a high density of EPO receptor (EPOR) in the basal state, signaling through these existing receptors in advance of injury (pharmacological preconditioning) might confer neuroprotection and therefore be potentially useful in situations of anticipated damage. Methods The authors compared asialoEPO, a molecule that binds to the EPOR with high affinity but with a brief serum half-life (t1/2 < 2 minutes), to EPO to determine whether a single dose (10 μg/kg of body weight) administered by intravenous injection 24 hours before 1 minute of spinal cord compression provides benefit as deter...Keywords
This publication has 62 references indexed in Scilit:
- Electrical Preconditioning Attenuates Progressive Necrosis and Cavitation following Spinal Cord InjuryJournal of Neurotrauma, 2004
- Adrenomedullin Protects Against Myocardial Apoptosis After Ischemia/Reperfusion Through Activation of Akt-GSK SignalingHypertension, 2004
- Hypoxia-Induced Stroke Tolerance in the Mouse Is Mediated by ErythropoietinStroke, 2003
- Preconditioning-mediated neuroprotection through erythropoietin?The Lancet, 2002
- Attenuation of Ischemic Brain EDEMA and Cerebrovascular Injury after Ischemic Preconditioning in the RatJournal of Cerebral Blood Flow & Metabolism, 2001
- Pharmacological Preconditioning With Lipopolysaccharide in the BrainStroke, 2000
- A model for assembly and activation of the GM-CSF, IL-3 and IL-5 receptors: Insights from activated mutants of the common β subunitExperimental Hematology, 2000
- Lithium protects cultured neurons against β‐amyloid‐induced neurodegenerationFEBS Letters, 1999
- Recombinant human erythropoietin inhibits iNOS activity and reverts vascular dysfunction in splanchnic artery occlusion shockBritish Journal of Pharmacology, 1999
- Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene ExpressionStroke, 1998