A Controlled Trial of a Prostacyclin and rt-PA in the Treatment of Severe Frostbite
- 13 January 2011
- journal article
- letter
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 364 (2), 189-190
- https://doi.org/10.1056/nejmc1000538
Abstract
Many alternatives have been proposed for the treatment of frostbite: hemodilution, platelet-aggregation inhibitors, low-molecular-weight heparin, alpha-adrenergic vasodilators, calcium-channel inhibitors, nonsteroidal antiinflammatory agents, prostacyclin analogues, fibrinolytic agents, and hyperbaric oxygen. None have been assessed in prospective randomized trials. Small retrospective studies1-3 suggest the efficacy of thrombolysis or prostacyclin analogues against spasm and thrombosis.Keywords
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