A guide for the diagnosis and management of gastrointestinal stromal cell tumors
- 14 April 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Gastroenterology & Hepatology
- Vol. 6 (6), 363-371
- https://doi.org/10.1038/nrgastro.2009.43
Abstract
Gastrointestinal stromal cell tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract and are frequently detected on routine endoscopy. Although only ∼ 10–30% of GISTs are clinically malignant, all may have some degree of malignant potential. Preoperative determination of malignancy risk can be estimated from tumor size and location, but reliable histopathologic criteria are not currently available. Given such biological uncertainty, accurate diagnosis is essential to differentiate these lesions from other truly benign, subepithelial tumors. Endoscopic ultrasound-guided fine-needle aspiration has emerged as an important procedure to secure a tissue diagnosis of a GIST. When encountering GISTs, gastroenterologists are faced with challenging management decisions, especially in the face of small, incidentally discovered lesions. The majority of localized GISTs are managed via surgical resection, although a select few may be observed using serial endoscopic ultrasound examinations. This Review provides a general overview of GISTs, with an emphasis on their endoscopic diagnosis, the management of localized disease, and the management of incidentally discovered GISTs.Keywords
This publication has 90 references indexed in Scilit:
- Laparoscopic wedge resection for gastric GIST: Long-term follow-up resultsEuropean Journal of Surgical Oncology, 2007
- Advantage of EUS Trucut biopsy combined with fine-needle aspiration without immediate on-site cytopathologic examinationGastrointestinal Endoscopy, 2006
- Long-term Outcomes of Laparoscopic Resection of Gastric Gastrointestinal Stromal TumorsAnnals of Surgery, 2006
- KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumoursEuropean Journal of Cancer, 2006
- Prospective study of a Trucut needle for performing EUS-guided biopsy with EUS-guided FNA rescueGastrointestinal Endoscopy, 2005
- Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate eraCancer, 2005
- A comparison of EUS features between CD-117 positive GI stromal tumors and CD-117 negative GI spindle cell tumorsGastrointestinal Endoscopy, 2003
- Prognostic Value ofKITMutation Type, Mitotic Activity, and Histologic Subtype in Gastrointestinal Stromal TumorsJournal of Clinical Oncology, 2002
- Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal TumorsThe New England Journal of Medicine, 2002
- Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal TumorsScience, 1998