Induction of erosive arthritis in mice after passive transfer of anti-type II collagen antibodies
- 1 September 1988
- journal article
- Published by Springer Science and Business Media LLC in Inflammation Research
- Vol. 25 (3-4), 352-359
- https://doi.org/10.1007/bf01965042
Abstract
The passive transfer of concentrated immunoglobulins or affinity-purified anti-collagen antibodies from sera of mice with type II collagen-induced arthritis can induce erosive arthritis in recipient animals. In both cases, the incidence of arthritis was over 60% and the inflammation persisted for at least two weeks. Radiography revealed bone destruction and apposition of a newly formed material while histologic examination showed cartilage and bone degradation, accompanied with synovitis and periarthritis. Inflammatory infiltrates were composed of polymorphonuclear leucocytes and lymphocytes, and were associated with a proliferation of connective tissue cells.Keywords
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