Are the precapillary sphincters and metarterioles universal components of the microcirculation? An historical review
Open Access
- 4 July 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in The Journal of Physiological Sciences
- Vol. 63 (5), 319-331
- https://doi.org/10.1007/s12576-013-0274-7
Abstract
The microcirculation is a major topic in current physiology textbooks and is frequently explained with schematics including the precapillary sphincters and metarterioles. We re-evaluated the validity and applicability of the concepts precapillary sphincters and metarterioles by reviewing the historical context in which they were developed in physiology textbooks. The studies by Zweifach up until the 1950s revealed the unique features of the mesenteric microcirculation, illustrated with impressive schematics of the microcirculation with metarterioles and precapillary sphincters. Fulton, Guyton and other authors introduced or mimicked these schematics in their physiology textbooks as representative of the microcirculation in general. However, morphological and physiological studies have revealed that the microcirculation in the other organs and tissues contains no metarterioles or precapillary sphincters. The metarterioles and precapillary sphincters were not universal components of the microcirculation in general, but unique features of the mesenteric microcirculation.Keywords
This publication has 90 references indexed in Scilit:
- Regulation of the human coronary microcirculationJournal of Molecular and Cellular Cardiology, 2012
- Structural arrangement of collagen fibrils in the periarterial connective tissue of the kidney: their functional relevance as a structural stabilizer against arterial pressureAnatomical Science International, 2011
- The Origin of the Biphasic Flow Response to Local Heat in SkinMicrocirculation, 2008
- Regulation of Blood Flow in the MicrocirculationMicrocirculation, 2005
- Distribution and origin of aminergic neurones in dog small intestineJournal of the Autonomic Nervous System, 1993
- Cytoarchitecture of the smooth muscles and pericytes of rat cerebral blood vesselsJournal of Neurosurgery, 1990
- Microangioarchitecture of rat parietal cortex with special reference to vascular "sphincters". Scanning electron microscopic and dark field microscopic study.Stroke, 1981
- Surface View of Pericytes on the Retinal Capillary in Rabbits Revealed by Scanning Electron MicroscopyArchivum histologicum japonicum, 1979
- Central dual innervation of arterioles and capillaries in the brain.Stroke, 1977
- The ultrastructure of mammalian arterioles and precapillary sphinctersJournal of Ultrastructure Research, 1967