Furan Based Cyclic Oligopeptides Selectively Target G-Quadruplex
- 10 October 2007
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 50 (23), 5539-5542
- https://doi.org/10.1021/jm070619c
Abstract
We report the binding properties of 18- and 24-membered cyclic oligopeptides developed from a novel furan amino acid, 5-(aminomethyl)-2-furancarboxylic acid, to G-quadruplex. Comparative analysis of the binding data of these ligands with G-quadruplex and double-strand DNA shows that 24-membered cyclic peptides are highly selective for telomeric G-quadruplex structures and thus can be used as a scaffold to target quadruplex structures at the genomic level.Keywords
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