Relative Cerebral Blood Volume Measurements in Intracranial Mass Lesions: Interobserver and Intraobserver Reproducibility Study
- 1 September 2002
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 224 (3), 797-803
- https://doi.org/10.1148/radiol.2243011014
Abstract
PURPOSE: To assess inter- and intraobserver reproducibility for different techniques of measuring relative cerebral blood volume (rCBV) in patients with intracranial mass lesions. MATERIALS AND METHODS: Three independent observers (neuroradiology fellows) who were blinded to the histopathologic diagnosis performed rCBV measurements in 50 patients with various intracranial mass lesions. Three different methods were compared. With method 1, placement of a single region of interest was guided by a color overlay map. With methods 2 and 3, the highest rCBV value and the mean of repeated rCBV measurements, respectively, were recorded. Calculations of the intraclass correlation coefficient, coefficient of variation (CV), and descriptive statistics were used to determine the levels of reproducibility. A multiple linear regression model was used to evaluate for possible explanatory factors for interobserver variance. RESULTS: Method 2 had, overall, the best reproducibility of all techniques, with an intraclass interobserver correlation coefficient of 0.71 (indicating good agreement), interobserver CV of 30%, and intraobserver CV in the range of 32%–41%. Measurement variations between observers correlated significantly (P < .001) with increasing rCBV values. CONCLUSION: In this study, interobserver and intraobserver reproducibility of rCBV measurements were clinically acceptable. © RSNA, 2002Keywords
This publication has 14 references indexed in Scilit:
- Dynamic susceptibility contrast MR imaging of plaque development in multiple sclerosis: Application of an extended blood-brain barrier leakage correctionJournal of Magnetic Resonance Imaging, 2000
- Glial Neoplasms: Dynamic Contrast-enhanced T2*-weighted MR ImagingRadiology, 1999
- Doppler perfusion index: an interobserver and intraobserver reproducibility study.Radiology, 1998
- Comparison of Cerebral Blood Volume Measurements Using the T1 and T2* Methods in Normal Human Brains and Brain TumorsJournal of Computer Assisted Tomography, 1997
- Microscopic susceptibility variation and transverse relaxation: Theory and experimentMagnetic Resonance in Medicine, 1994
- Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings.Radiology, 1994
- Perfusion imaging with NMR contrast agentsMagnetic Resonance in Medicine, 1990
- Gliomas: classification with MR imaging.Radiology, 1990
- Dynamic imaging with lanthanide chelates in normal brain: Contrast due to magnetic susceptibility effectsMagnetic Resonance in Medicine, 1988
- ON THE METHODS AND THEORY OF RELIABILITYThe Journal of Nervous and Mental Disease, 1976