NIH Molecular Libraries Initiative
Top Cited Papers
- 12 November 2004
- journal article
- policy forum
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 306 (5699), 1138-1139
- https://doi.org/10.1126/science.1105511
Abstract
The Molecular Libraries Initiative (MLI) of the NIH Roadmap for Medical Research is a bold set of programs to facilitate the use of small molecules in the public sector and expand the reach of small-molecule technologies to define gene, cell, and organism function in health and disease. The initiative described in this Policy Forum has three components: the Molecular Libraries Screening Centers Network; cheminformatics initiatives including a new public compound database (PubChem); and technology development initiatives in chemical diversity, cheminformatics, assay development, screening instrumentation, and predictive ADMET. All research tools and results will be made publicly available without encumbrance. The small-molecule tools and technologies produced by the MLI will accelerate gene function determination, target validation, and downstream drug development.Keywords
This publication has 12 references indexed in Scilit:
- Finishing the euchromatic sequence of the human genomeNature, 2004
- Exploring the chemogenomic knowledge space with annotated chemical librariesCurrent Opinion in Chemical Biology, 2004
- Francis S. CollinsNature Reviews Drug Discovery, 2004
- NIH Gears Up for Chemical GenomicsScience, 2004
- NIH Dives Into Drug DiscoveryScience, 2003
- The NIH RoadmapScience, 2003
- Target discoveryNature Reviews Drug Discovery, 2003
- Hit and lead generation: beyond high-throughput screeningNature Reviews Drug Discovery, 2003
- The price of innovation: new estimates of drug development costsJournal of Health Economics, 2003
- The druggable genomeNature Reviews Drug Discovery, 2002