Genetics of Aging in Caenorhabditis elegans
Open Access
- 28 September 2007
- journal article
- review article
- Published by Public Library of Science (PLoS) in PLoS Genetics
- Vol. 3 (9), e129-1571
- https://doi.org/10.1371/journal.pgen.0030129
Abstract
A dissection of longevity in Caenorhabditis elegans reveals that animal life span is influenced by genes, environment, and stochastic factors. From molecules to physiology, a remarkable degree of evolutionary conservation is seen.Keywords
This publication has 129 references indexed in Scilit:
- daf-16 Protects the Nematode Caenorhabditis elegans During Food DeprivationThe Journals of Gerontology: Series A, 2006
- The Caenorhabditis elegans Heterochronic Regulator LIN-14 Is a Novel Transcription Factor That Controls the Developmental Timing of Transcription from the Insulin/Insulin-Like Growth Factor Gene ins-33 by Direct DNA BindingMolecular and Cellular Biology, 2005
- Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in miceGenes & Development, 2005
- C. elegans tubby regulates life span and fat storage by two independent mechanismsCell Metabolism, 2005
- Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity AssuranceJournal of Biological Chemistry, 2004
- The TOR pathway interacts with the insulin signaling pathway to regulateC. eleganslarval development, metabolism and life spanDevelopment, 2004
- Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling PathwayCurrent Biology, 2004
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature, 2003
- The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanismsGenes & Development, 1999
- The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling PathwayMolecular Cell, 1998