Ergot-Induced Inhibition of Pituitary Tumor Growth in Rats
- 28 April 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4033), 417-418
- https://doi.org/10.1126/science.176.4033.417
Abstract
Daily injections of ergocornine or ergonovine, for 3 weeks, into rats carrying a prolactin- and growth hormone—secreting pituitary tumor (MtW15) induced significant regression or inhibition of tumor growth, whereas ergocryptine had no significant effect. Ergocornine caused a decrease in cells and a disappearance or pycnosis of nuclei in the tumor tissue, and a reduced concentration of prolactin in blood.Keywords
This publication has 4 references indexed in Scilit:
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- Direct Inhibition by Ergocornine of Pituitary Prolactin ReleaseEndocrinology, 1971
- Effects of Ergocornine on Serum Prolactin and LH, and on Hypothalamic Content of PIF and LRFEndocrinology, 1971
- Ultrastructural, Histologic and Hormonal Characterization of a Prolactin-Rich Human Pituitary TumorJournal of Clinical Endocrinology & Metabolism, 1969