Assays for angiogenesis: A review
- 1 January 1991
- journal article
- review article
- Published by Elsevier BV in Pharmacology & Therapeutics
- Vol. 51 (1), 1-11
- https://doi.org/10.1016/0163-7258(91)90038-n
Abstract
Accurate, reliable quantitation of the neovascular (angiogenic) response, both in vitro and in vivo, is an essential requirement for the study of new blood vessel growth. Over many years, ingenious ways have been developed for measuring this process, and they have contributed much to our present understanding of the vasculogenesis and angiogenesis that accompany normal embryonic development, lactation and wound healing, as well as tumor growth and a variety of other disease states ranging from diabetic retinopathy to autoimmune vasculitis. In this review we describe and evaluate the methodology and specific features of some of the most frequently used of these assays.Keywords
This publication has 57 references indexed in Scilit:
- Wound Healing AngiogenesisJournal Of Trauma-Injury Infection and Critical Care, 1990
- Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2)Biochemical and Biophysical Research Communications, 1990
- Vascular endothelial differentiation in sponge matrix allograftsHuman Immunology, 1990
- On mast-cell-mediated angiogenesis in the rat mesenteric-window assayInflammation Research, 1990
- Junctional communication is induced in migrating capillary endothelial cells.The Journal of cell biology, 1989
- Induction of angiogenesis during the transition from hyperplasia to neoplasiaNature, 1989
- A new image analysis method for the quantification of neovascularizationExperimental pathology, 1984
- Utilization of image analysis for the quantification of vascular responses in the chick chorioallantoic membraneExperimental pathology, 1984
- A simple procedure for the long-term cultivation of chicken embryosDevelopmental Biology, 1974
- Differentiation of vascular endothelium in the chick chorioallantois: A structural and autoradiographic studyDevelopmental Biology, 1974