Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration
- 1 February 1989
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 3 (2), 174-177
- https://doi.org/10.1096/fasebj.3.2.2914628
Abstract
Adult rat hepatocytes cultured in a collagen sandwich system maintained normal morphology and a physiological rate of albumin secretion for at least 42 days. Hepatocytes cultured on a single layer of...Keywords
This publication has 8 references indexed in Scilit:
- Cell contact but not junctional communication (dye coupling) with biliary epithelial cells is required for hepatocytes to maintain differentiated functionsExperimental Cell Research, 1987
- Persistence of liver-specific messenger RNA in cultured hepatocytes: different regulatory events for different genes.The Journal of cell biology, 1987
- Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.JCI Insight, 1987
- Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro.1986
- Maintenance of differentiated rat hepatocytes in primary culture.Proceedings of the National Academy of Sciences, 1985
- Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell typeExperimental Cell Research, 1983
- Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture.Proceedings of the National Academy of Sciences, 1982
- Influence of collagen gel on the orientation of epithelial cell polarity: follicle formation from isolated thyroid cells and from preformed monolayers.The Journal of cell biology, 1981